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M9630102.TXT
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1996-02-27
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Document 0102
DOCN M9630102
TI Vaccination protects against in vivo-grown feline immunodeficiency virus
even in the absence of detectable neutralizing antibodies.
DT 9603
AU Matteucci D; Pistello M; Mazzetti P; Giannecchini S; Del Mauro D;
Zaccaro L; Bandecchi P; Tozzini F; Bendinelli M; Department of
Biomedicine, University of Pisa, Italy.
SO J Virol. 1996 Jan;70(1):617-22. Unique Identifier : AIDSLINE
GENBANK/M25381
AB So far, vaccination experiments against feline immunodeficiency virus
have used in vitro-grown virus to challenge the vaccinated hosts. In
this study, cats were vaccinated with fixed feline immunodeficiency
virus-infected cells and challenged with plasma obtained from cats
infected with the homologous virus diluted to contain 10 cat 50%
infectious doses. As judged by virus culture, PCRs, and serological
analyses performed over an 18-month period after the challenge, all of
the vaccinated cats were clearly protected. Interestingly, prior to
challenge most vaccines lacked antibodies capable of neutralizing a
fresh isolate of the homologous virus.
DE Amino Acid Sequence Animal Antibodies, Viral/*BLOOD/IMMUNOLOGY Base
Sequence Cats Cell Line DNA Primers Feline Acquired Immunodeficiency
Syndrome/*PREVENTION & CONTROL Female Immunodeficiency Virus,
Feline/*IMMUNOLOGY/ISOLATION & PURIF Molecular Sequence Data
Neutralization Tests Repetitive Sequences, Nucleic Acid Support,
Non-U.S. Gov't T-Lymphocytes/IMMUNOLOGY Viral Vaccines/*ADMINISTRATION
& DOSAGE JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).